b'Hard-Shell Capsule OptionsGelatin,typicallysourcedfrom collagen, is the base material for theshellmatrixofliquid-filled capsules.Vegetarianoptions includeapolymer,suchas hydroxypropylmethylcellulose (HPMC),potatostarch,and carrageenan from seaweed.When it comes to formulation development and manufacturing, both of these options provide numerous benefits:Ability to use excipients with higher melting points when using HPMC capsulesImproved content uniformity of low-dose active and potent compoundsEnhanced stabilityLower moisture contentLess gas transmissionImproved bioavailabilityA Complete, Attractive SolutionFornoveldevelopment,liquid-filled,hard-shellcapsuleshavethe potential to transform formulation challenges into simple solutions. Drugswithpoorwatersolubilityandbioavailability,withlow melting points, potent drugs, hot liquids, and medications where a sustained-release profile is desirable, are all ideally suited to liquid-filled capsules. They offer a highly marketable dosage form due to theircapabilitytoencapsulatedifferentcombinationsoftablets, pellets, caplets, and capsules in liquid. Last but not least, they offer patient benefits with increased bioavailability and sustained release drug delivery.References1. https://www.americanpharmaceuticalreview.com/Featured-Articles/573402-Poor-Solubility-Where-Do-We-Stand-25-Years-after-the-Rule-of-Five/'