b'TOP REASONSLiquid-Filled Capsules (LFCs) Can Benefit Your Clinical TrialsPoor Water Solubility/BioavailabilityLow Dose High PotencyDrug profiles for which LFCs are more suitableSpeed1. Poor Water Solubility/BioavailabilityBioavailability and solubility of poorly water-soluble drugs can be significantly enhanced when formulated as a liquid in a hard-shell capsule. Poor water solubility and bioavailability are frequent issues in the pharmaceutical industry and represent a significant barriertosuccessfuldrugformulation.Estimatesshowthat 40%90% of new compounds have low solubility. This is especially true when poorly water-soluble APIs are formulated as tablets.'