LEAD OPTIMIZATION STUDIES: ADVANCING DRUG DISCOVERY
Altasciences specializes in lead optimization studies, helping you identify the most promising drug candidates through precise, data-driven preclinical screening. Our expert scientists tailor each study to your unique needs, utilizing efficient non-GLP screening protocols to accelerate decision-making. With streamlined study designs, clear data visualization, and rapid turnaround times, we provide actionable insights to advance your drug discovery pipeline.
DATA-DRIVEN LEAD OPTIMIZATION STUDIES FOR DRUG DEVELOPMENT
Altasciences’ lead optimization studies bridge the gap between early-stage in vitro screening and preclinical safety assessments, accelerating the path to human clinical trials. Our comprehensive testing evaluates the effects of promising drug candidates using single-dose, 3-5 day, and 10–14 day repeat-dose studies in rodent and non-rodent species. We can also test multiple drug candidates in parallel, providing comparative data for informed decision-making and optimized selection.
We conduct pharmacokinetic (PK) and toxicology assessments, dose-response studies, and safety profiling to refine lead compounds effectively. Assessments usually focus on clinical observations, hematology, gross observations, and pathological evaluations of major organs. Our toxicologists help you to understand how the drug interacts with biological systems, its distribution, metabolism, and excretion (ADME), and its overall safety profile. These studies help identify any potential toxic effects and provide critical data on the dosage and administration routes that are most effective.
Conducting in vivo lead optimization studies also involves assessing the therapeutic efficacy of drug candidates in disease models. By testing the compound in animals that mimic human disease conditions, you can gather valuable insights into its potential effectiveness and side effects in treating the target condition. This phase often includes dose-response studies to determine the optimal dose range and repeated dosing to observe any long-term effects. The data obtained from these animal studies are essential for refining the drug candidate and advancing it to the next stages of development.
WHAT WE OFFER
At Altasciences, our lead optimization services are designed to provide rapid, high-quality preclinical data.
We offer:
- Comprehensive lead optimization studies using single-dose and repeat-dose models (3-5 days, 10-14 days) in rodent and non-rodent species.
- Expert toxicology and pharmacokinetic assessments for informed decision-making.
- Advanced preclinical facilities with cutting-edge equipment for accurate and reproducible results.
- Tailored study designs to maximize drug candidate evaluation efficiency.
- A team of experienced researchers and scientists dedicated to conducting lead optimization studies.
Fast-track your drug discovery with expert lead optimization studies. Our scientists deliver rapid, decision-ready results for confident lead candidate selection.
ENHANCE YOUR DRUG DISCOVERY JOURNEY
Altasciences’ fully integrated service offering allows us to operate as a cohesive, devoted, and accessible team to swiftly resolve the issues you face during this initial phase of drug development. Recognizing that every project is unique, our scientists design lead optimization studies on a case-by-case basis and are flexible to cater to your specific needs. We provide a comprehensive range of services that are fully customizable and produce high-quality, validated hit compounds for your drug discovery project.
OUR FULL SPECTRUM OF PRECLINICAL RESEARCH SERVICES
Dive deeper into Altasciences' extensive range of preclinical research services. From early phase development to clinical trial readiness, our comprehensive offering ensures a seamless transition through each stage of drug development.
THERAPEUTIC AREAS
Our deep expertise and capabilities in a broad range of therapeutic areas encompasses preclinical and early clinical studies for both small molecules and biologics. We can manage your entire program, as well as provide comprehensive support research services and bioanalytical expertise.