alta-icon logo-altasciences

EN - Main navigation

  • Navigating COVID-19
  • Proactive Drug Development
  • Solutions
  • About Us
  • Resource Center
  • Careers
  • News & Events
  • Contact Us
  • Participate in a study
  • Request for information
Français
  • Home
  • Our Solutions
  • Current: Bioanalytical Services

Bioanalytical Solutions | Laboratory Services

Altasciences’ bioanalytical team specializes in ligand binding assays (LBA), mass spectrometry, immunology, biomarkers, flow cytometry, and PCR, from discovery to preclinical to Phase IV. Our team of experts operates in three strategic locations near our preclinical and clinical sites, providing the full-service resources to meet your everyday requirements. Whether as a stand-alone service or part of an integrated program, we aim to provide top-quality data for TK, PK, and PD determinations to support your preclinical and clinical studies.

Ask Our Experts
Assay List

Share this page

  • Experts in Laboratory Services
  • Bioanalytical Solutions
  • LC-MS/MS AND LBA
  • FAQ

Experts in Laboratory Services

We offer a full range of bioanalytical services conducted in state-of-the-art, purpose-built laboratories at our locations in the U.S. and Canada, with designated containment level 2 areas for work with Risk Group 2 pathogens. Staffed by highly-skilled analysts, with shifts running 24/7 (as needed), we have the capacity to run up to 720,000  samples/year, large and small molecules, with monitored storage (fridges and freezers). Precision bioanalytical services are available as a stand-alone, or part of a package of services.

260+

HIGHLY TRAINED
SPECIALISTS

720K+

SAMPLES CAPACITY
PER YEAR

685+

ASSAYS COVERING
620+ MOLECULES

Bioanalytical Solutions

We have the solution for all of your bioanalytical needs. Our state-of-the-art laboratories are fully equipped and staffed to perform individual assays and support your preclinical and clinical studies. Most importantly, we ensure the success of your projects by anticipating challenges throughout the process.

  • Translational Biomarkers

    Translational Biomarkers

    Translational Biomarkers

    Support both preclinical and clinical studies covering many disease indications, such as oncology, metabolic disease, neurology, diabetes, inflammation, and more.
    LEARN MORE
  • Microsampling

    Microsampling

    Microsampling

    Microsampling (the use of low volume blood draws) supports preclinical and clinical trials with less invasive procedures that deliver the same scientific accuracy and precision.
    LEARN MORE
  • Flow Cytometry

    Flow Cytometry

    Flow Cytometry

    In-house flow cytometry expertise for accurate, efficient cell counting, biomarker detection, and protein engineering tasks for preclinical and clinical studies.
    LEARN MORE
  • Oligonucleotides

    Oligonucleotides

    Oligonucleotides

    Altasciences has expertise in the development of highly sensitive bioanalytical assays for the quantitation of oligonucleotides in complex biological matrices such as eye, liver, or brain tissue, adapted to the different critical parameters of your preclinical and clinical studies.
    LEARN MORE
  • Bioanalysis Platforms

    Platforms

    Platforms

    From small to large molecules, as well as sample preparation automation, Altasciences can help you expedite your study or program, with precise and quality data with a list of our state-of-the-art platforms.
    LEARN MORE

Mass Spectrometry and Ligand Binding

Our unique array of platforms and large list of validated assays ensures the most effective methods for your individual programs.

Our preclinical and clinical laboratory space, in both the U.S. and Canada, includes the following:

  • Designated containment Level 2 (CL2) areas for work with Risk Group 2 (RG2) pathogens. Because of our work with NHPs, our preclinical site has BSL2 designation for various species. Our bioanalytical services analysts are available 24/7 depending on your program needs, to ensure that we process your samples within agreed-upon timelines.

From discovery to preclinical and clinical pharmacology, we work in accordance with GLP and current FDA/EMA guidelines for both small and large molecules, including immunogenicity and biomarkers. Each bioanalytical validation and phase for sample analysis has an assigned bioanalytical principal investigator.

We have experience with a wide spectrum of biological matrices in both animal species and humans, including:

  • Serum
  • Plasma
  • Blood
  • Urine
  • Feces
  • Tissues
  • Cerebrospinal fluid
  • Vitreous humor

Our capabilities include supporting microsampling (Mitra® VAMS®) and dried blood spots for preclinical and clinical programs.

Assigned bioanalytical services study personnel maintain open and constant communication with key stakeholders through regular conference calls and data sharing, adjusting, and managing the project progression as needed.

Laboratory services include:
Mass Spectrometry (LC-MS/MS)

Extensive experience with small molecules has provided an extensive in-house database of 685 assays, with more being added all the time.

  • Small molecules, peptides, proteins, oligonucleotides
  • Experience with labile metabolites, endogenous compounds
  • HRMS equipment
  • Nanoflow, microflow
  • Principal Investigators with anesthesiology, urology, and pediatrics specializations

LC-MS/MS

We leverage our decades of experience in LC-MS/MS to successfully transition our competencies to peptides, proteins (intact and surrogate peptide quantification), monoclonal antibodies, and antibody-drug conjugates for both preclinical and clinical stages of drug development. We are adept at performing automated immunoaffinity sample preparation, and producing high-throughput assays with impressive sensitivity.

Our capabilities are supported by over 30 LC-MS/MS instruments, including Sciex 5000, 5500, 6500+, and Selexion with Nexera UHPLCs. Our HRMS include the Sciex 5600, 6600, and ThermoFisher Q-Exactive. We have micro-flow and nano-flow capabilities for the front end of our HRMS systems.

Ligand Binding Assay

Wide range of large molecule bioanalytical capabilities, using both ligand binding and mass spectrometry platforms.

  • Electrochemiluminescence
  • MSD Imager
  • Immunogenicity assays
  • Quantitative ELISA assays
  • Biomarker panels
  • Cell-based assays
  • Flow cytometry
  • Gene therapy

LIGAND BINDING

Our ligand binding group offers support for Immunogenicity, PD, PK, BE, and biosimilar studies for both preclinical and clinical stages of drug development.

We have nearly a decade of experience with small and large molecules, such as oligonucleotides, small peptides, chemical elements, proteins, bi-specific antibodies, monoclonal antibodies, and antibody-drug conjugates. Depending on the level of sensitivity, complexity of your drug, or the need to multiplex or have a high-throughput sample analysis for your study, our scientists will propose the most suitable equipment for your needs.

Our ligand binding assay types:

  • Immunogenicity assays:
    • ADA: screening, confirmatory and titration
    • nAb by non-cell based and cell-based assays
  • Quantification methods using various platforms
  • Hybridization ELISA/ECLIA of various types (ligation, dual hybridization)
  • Functional cell-based assays
  • Biomarkers
  • Cell lineage and functional immunophenotyping by flow cytometry
  • PCR analysis (Droplet digital PCR, Quantitative PCR)
  • Cytokine/Chemokine Analysis
  • Electrochemiluminescence (ECL)

Our ligand binding equipment includes:

  • Mesoscale S600 Electrochemiluminescence Sector Imager
  • BioTek Synergy H4 Multimode Plate Reader using Absorbance, Fluorescence, or Luminescence
  • Luminex 200 System
  • Simoa HD-1 Analyzer
  • BioTek EL406 Microplate Washer/Dispenser
  • BD Biosciences FACSCantoTM II Cytometer
  • SpeedVac for tissue extraction
  • Percellys®  Evolution Homogenizer
Other
  • Transgene expression and RNA analysis
  • Cell lineage and functional immunophenotyping by flow cytometry
  • Droplet digital PCR
  • Quantitative PCR
  • Antibody and antibody-drug conjugates
  • Translational biomarkers

Altasciences’ Bioanalytical Laboratories

  • Over 260 highly skilled bioanalytical experts
  • From discovery to preclinical to Phase IV — Method development, validation, and sample analysis
  • LC-MS/MS and ligand binding capabilities
  • Capacity to process over 60,000 samples per month
  • Small and large molecule program support
  • In-house database of over 685 assays covering over 650 molecules
  • Expertise in many specialized areas
    • PCR
    • Flow cytometry
    • Microsampling
    • Immunogenicity
    • Oligonucleotides
    • PBMC
    • Biomarkers
    • Cell-based assays
    • and more
Our Bioanalytical Facilities Laval Seattle

 

THERAPEUTIC AREAS

Our deep expertise and capabilities in a broad range of therapeutic areas encompasses preclinical and early clinical studies for both small molecules and biologics. We can manage your entire program, as well as provide comprehensive support research services and bioanalytical expertise.

 

Learn More

Related Resources

Fact Sheets

Bioanalytical Services

Bioanalysis Services

Ligand Binding Assays

Ligand Binding Assays

Bioanalysis of Biologics using Mass Spectrometry

Bioanalysis of Biologics using Mass Spectrometry

Video

Bioanalytical Services at a Glance

Bioanalytical Services at a Glance

Step Inside our Bioanalytical Laboratories

Step Inside our Bioanalytical Laboratories

Bioanalysis - FAQs

Are your bioanalytical services adaptable to different drug development program requirements?

Our bioanalytical services are entirely flexible. You can partner with us for stand-alone analysis of your samples, or we can conduct our precision bioanalytical services as part of a full drug development package. We offer LC-MS/MS, ligand binding, or hybrid processes for your large or small molecules, including specialized large molecule LC-MS and a dedicated ligand binding lab space, for preclinical and clinical samples. We also offer nonclincal laboratory services, such as anatomic and clinical pathology, and toxicokinetics.

How long has Altasciences been providing bioanalytical services?

We have been delivering excellence in bioanalytical services for more than 25 years, and we have more than 200 experts working at our labs. With shifts running 24/7 if needed, our laboratory teams are able to process as many as 60,000 samples per month.

How does Altasciences ensure optimal communication between their clients, and their bioanalytical services teams?

Every project Altasciences takes on is managed by a Bioanalytical Principal Investigator, who works hand in hand with you through every step of the project. We ensure accurate and complete capture of your requirements, so that you only have to Tell Us Once™.

Do your laboratories have the capability to handle specialized projects such as microsampling, gene therapy, oligonucleotides, etc?

Yes, we can accommodate your bioanalytical or preclinical needs for biologics, gene therapies, oligonucleotides and other precision requirements. We have state-of-the-art equipment, and highly skilled experts for your specialized needs such as large molecule LC-MS/MS, ligand binding, gene therapy analysis, and microsampling. We also have designated containment Level 2 areas for work with risk group 2 pathogens.

Sign up for exclusive content

Join our list of 10,000+ VIP members and have access to our exclusive content.

Stay connected

  • linkedin
  • youtube

Footer

    • Solutions

      • Preclinical Services
      • Clinical Services
      • Manufacturing and Analytical Services
      • Bioanalytical Services
      • Research Support Services
      • Development Programs
    • News & Events

      • Altasciences Events
      • Press Releases
      • Altasciences in the News
      • Press Kit
    • Resource Center

      • The Altascientist
      • Webinars/Podcasts
      • eBulletins
      • Newsletters
      • Scientific Publications
      • Blog
      • Videos
    • Study Types

      • Preclinical
      • Lead Optimization
      • Pharmacology
      • Pharmacokinetics/​Pharmacodynamics
      • Acute Toxicology
      • Dose Range Finding​/​Maximum Tolerated Dose
      • Repeated Dose Toxicity
      • Safety Pharmacology
      • Sub-Chronic/Chronic, Repeated Dose Toxicity
      • Clinical
      • First in Human
      • Proof of Concept
      • Bioavailability/Bioequivalence
      • Pharmacokinetics in Special Populations
      • Human Abuse Potential
      • Driving Simulation
      • Drug-Drug Interaction
      • QT Assessment
      • Renal and Hepatic Impaired
      • Imaging
      • Biologics​/​Biosimilars
      • Cannabis
    • Therapeutic Areas

      • Cardiology
      • Dermatology
      • Gastroenterology
      • Hematology
      • Immunology
      • Infectious Diseases
      • Metabolism and Endocrinology
      • Neurology
      • Oncology
      • Ophthalmology
      • Orthopedics
      • Psychiatry
      • Respirology
      • Rheumatology
      • Substance Abuse
      • Urology
      • Women’s Health
    • About us

      • History
      • Our Origins
      • Awards
      • Testimonials
    • Careers

    • Contact Us

    • Locations

    • Stay connected

      • Facebook
      • Youtube

2021 © Altasciences. All Rights Reserved.

Cookie Policy | Privacy Policy

Have a question?

I'd be happy to help.

Captcha is required.