Ligand Binding
Our ligand binding group offers support for Immunogenicity, PD, PK, BE, and Biosimilar studies for both preclinical and clinical stages of drug development.
We have nearly a decade of experience with small and large molecules, such as oligonucleotides, small peptides, chemical elements, proteins, bi-specific antibodies, monoclonal antibodies, and antibody-drug conjugates. Depending on the level of sensitivity, complexity of your drug, or the need to multiplex or have a high-throughput sample analysis for your study, our scientists will propose the most suitable equipment for your needs.
Our Ligand binding assay types:
- Immunogenicity assays:
- ADA: screening, confirmatory and titration
- nAb by non-cell based and cell-based assays
- Quantification methods using various platforms
- Hybridization ELISA/ECLIA of various types (ligation, dual hybridization)
- Functional cell-based assays
- Antibody response (TDAR)
- Biomarkers
- Cell lineage and functional immunophenotyping by flow cytometry
- PCR analysis (Droplet digital PCR, Quantitative PCR)
- Cytokine/Chemokine Analysis
- Electrochemiluminescence (ECL)
Our ligand binding equipment includes:
- Mesoscale S600 Electrochemiluminescence Sector Imager
- BioTek Synergy H4 Multimode Plate Reader using Absorbance, Fluorescence, or Luminescence
- Luminex 200 System
- Simoa HD-1 Analyzer
- BioTek EL406 Microplate Washer/Dispenser
- BD Biosciences FACSCantoTM II Cytometer
- SpeedVac for tissue extraction
- Percellys® Evolution Homogenizer