Accelerating Decentralized Clinical Trials with Precise ASO Analysis

In this poster presentation, Dr. Mingluan Chen discusses the first successful application leveraging the Capitainer® qDBS device, for the quantitative bioanalysis of Fomivirsen ASO and its 5’ n-1 metabolite from dried blood micro samples using a hybridization LC-MS/MS workflow.


The ability to quantify ASOs accurately and efficiently in dried blood samples means critical patient populations may be more readily accessible for decentralized clinical trials. This can lead to faster, more efficient research and improved patient outcomes.

You may also be interested in the below resources: 


Microsampling Capabilities

Oligonucleotide Capabilities

Research Articles:

A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF, and Tissue Samples 

Accurate Quantification of ASOs in Mouse Serum Using Microsampling LC-MS/MS​​​​​​    

Poster Presentations:

Application of Mitra® Microsampling for the Quantitative Bioanalysis of ASOs 

Development of a Surrogate Cerebrospinal Fluid Matrix for Quantitative Analysis of ASOs by Hybridization LCMS