All Things Oligonucleotides!

The therapeutic development of antisense oligonucleotides (ASOs) has expanded its reach to encompass diseases like Huntington's, Alzheimer's, and Parkinson's.

Given their ability to pinpoint disease pathogenesis's root cause, ASOs are a hopeful avenue for addressing stubborn illnesses and genetic disorders.

Explore our resource library to learn more about oligonucleotides and their potential, from synthesis techniques to innovative applications.

Poster Presentations:

Application of Mitra Microsampling for the Quantitative Bioanalysis of ASOs 
Development of a Surrogate Cerebrospinal Fluid Matrix for Quantitative Analysis of ASOs by Hybridization LC-MS 
Development of an Oligonucleotide Drug Immunogenicity Assay 


Bioanalytical Development for the Analysis of ASOs

Special Issue of The Altascientist:

Antisense Oligonucleotides (with two case studies!)

Research Articles:

A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF, and Tissue Samples

Accurate Quantification of ASOs in Mouse Serum Using Microsampling LC-MS/MS

Altasciences has been recognized as a 2023 CRO Leadership Award Champion in the Capabilities category, as voted by you in ISR’s annual CRO Quality Benchmarking survey.