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A must-read case study on drug-drug interactions in our latest issue of The Altascientist

The Altasciences Issue 7
Download full issue and case study

Effective pharmaceutical therapies ― Understanding the intrinsic and extrinsic factors that alter exposure to limit adverse effects and maximize treatment response

Drugs play a critical role in the prevention and treatment of diseases. Though they are necessary to sustain and enhance the quality of patients’ lives, the increasing number of available drugs on the market leads to a greater potential for drug-drug interactions (DDIs). More complex drug regimens with multiple compounds administered to treat one condition, or different compounds given to treat comorbidities, are contributing factors. DDIs as well as drug-alcohol or food effects are examples of how extrinsic factors can alter the exposure of drugs and cause serious adverse effects or a reduction in efficacy. Furthermore, intrinsic factors such as age, gender, comorbidities or genetics can also potentially alter drug exposure.

Clinical studies can be used to determine the effects these intrinsic and extrinsic factors can have on systemic exposure, and investigate possible interactions. In vitro studies…

Download full issue and case study to learn about clinical trials for drug interactions.


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