Hybridization LC-MS/MS Workflow to Quantify an siRNA Drug Candidate in Plasma, CSF, and Tissues

Discover how our scientists successfully applied the hybridization LC-MS/MS workflow to quantify an siRNA drug candidate in plasma, CSF, and tissues. With the use of specific capture probes, this novel analytical approach can be applied to the quantitative bioanalysis of both single- and double-stranded oligonucleotides.