Bioanalysis

  • Bioanalysis
  • Laboratory Sciences Resource Library

     

    A Wealth of Information at Your Fingertips

    Explore Altasciences’ bioanalytical resources for comprehensive solutions tailored to your specific requirements. Altasciences’ bioanalytical team specializes in assay development from discovery to preclinical to Phase IV for both small and large molecules.
     

    The Altascientist—A Scientific Journal 
            
    The Evolution and Advancement of Liquid Chromatography-Mass Spectrometry in Drug Development. Read or listen to the issue>>>

    Validation of Immunogenicity Assays. Read or listen to the issue>>>

    Microsampling in Drug Development. Read or listen to the issue>>>
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    eBook

    Key Biomarkers of Immunomodulation. Read or listen to the eBook>>>


    Webinars 

    Uses of Digital Droplet PCR (ddPCR) in Preclinical Research. Watch the webinar>>>

    Development of a Cell-Based Assay for Dual Purposes: to Support Drug Potency and Characterize Immunogenicity. Watch the webinar>>>
     

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    Speak with an expert today to learn more about our bioanalytical solution.

     

    Have five more minutes? Check out these webpages:

    Bioanalytical Services 
    Assay List

     

    Supporting the Future of Immunomodulatory Drugs

     

    Achieve Critical Milestones in Your Drug Development Program

    At Altasciences, we specialize in diverse immunomodulators, including proteins, oligonucleotides, biologics, bispecific antibodies, and gene therapy.

    Our evaluations count on essential biomarkers, like cytokines, complement factors, immune cell subtyping, and functional measurements.

    Rely on us for:

    • precise drug quantitation and biomarker assessment;
    • state-of-the-art bioanalytical platforms to monitor multiple aspects of immunomodulation in various species;
    • bioanalytical teams with relevant experience handling pathogens and working with infectious samples for your vaccine development programs; and
    • labs equipped with containment Level 2 (CL2) areas for handling pathogens within the Risk Group 2.

    VIEW FACT SHEET


    Need more guidance? Send us a message.

     

    You may also be interested in the below resources:
    Fact Sheet: Immunogenicity Testing
    eBook: Key Biomarkers of Immunomodulation
    Webpage: Bioanalytical Platforms

     

    Accelerating Decentralized Clinical Trials with Precise ASO Analysis

    In this poster presentation, Dr. Mingluan Chen discusses the first successful application leveraging the Capitainer® qDBS device, for the quantitative bioanalysis of Fomivirsen ASO and its 5’ n-1 metabolite from dried blood micro samples using a hybridization LC-MS/MS workflow.

    WATCH PRESENTATION

    The ability to quantify ASOs accurately and efficiently in dried blood samples means critical patient populations may be more readily accessible for decentralized clinical trials. This can lead to faster, more efficient research and improved patient outcomes.

    You may also be interested in the below resources: 

    Webpages:

    Microsampling Capabilities

    Oligonucleotide Capabilities

    Research Articles:

    A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF, and Tissue Samples 

    Accurate Quantification of ASOs in Mouse Serum Using Microsampling LC-MS/MS​​​​​​    

    Poster Presentations:

    Application of Mitra® Microsampling for the Quantitative Bioanalysis of ASOs 

    Development of a Surrogate Cerebrospinal Fluid Matrix for Quantitative Analysis of ASOs by Hybridization LCMS 

    Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri

    Laval, Québec, October 31, 2023Altasciences is pleased to announce the completion of its laboratory facilities in Columbia, MO.

    The newly expanded, 8,000-square-foot space, which includes a test material department, featuresL-R: Dr. Lynne Le Sauteur, Dr. Susan Ohorodnik, Ian Vanterpool, and Michael Qualls, 2023 state-of-the-art equipment and forty-eight workbenches, with a vast range of services, including ligand binding assays, flow cytometry, biomarker analysis, and cell culture capabilities.

    “This laboratory expansion is a significant step forward in our ability to meet the increasing needs of sponsors. Our focus on growing our bioanalytical capabilities highlights Altasciences' mission to help develop potentially life-saving therapeutics, and get them to market faster,” said Marie-Hélène Raigneau, Co-chief Operating Officer, Altasciences. “Our integrated CRO/CDMO services combine bioanalytical services with preclinical and clinical study solutions, manufacturing services, and all complementary research support services, for maximum efficiency.” 

    This is Altasciences’ third purpose-built laboratory. Altasciences’ laboratory sciences has the scientific, regulatory, and operational expertise for quantitation of drugs and biomarkers from discovery to preclinical to Phase IV, using bioanalysis platforms including mass spectrometry, ligand binding assay, PCR, flow cytometry, ELISpot, and cell based assays in routine and specialized areas such as immunomodulation and cell and gene therapy. All three laboratories across North America are uniformly designed and managed.  

    Whether as a standalone bioanalytical service or as part of an integrated program, Altasciences provides top-quality data for TK, PK, and PD determinations to support preclinical and clinical studies.

    About Altasciences
    Altasciences is an integrated drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services. For over 25 years, Altasciences has been partnering with sponsors to help support educated, faster, and more complete early drug development decisions. Altasciences’ integrated, full-service solutions include preclinical safety testing, clinical pharmacology and proof of concept, bioanalysis, program management, medical writing, biostatistics, clinical monitoring, and data management, all customizable to specific sponsor requirements. Altasciences helps sponsors get better drugs to the people who need them, faster. To learn more about Altasciences, visit altasciences.com
     

    Retrospective Safety Evaluation of Tyrosine Kinase Inhibitor Products When Administered in Single Dose in Crossover Studies to Healthy Volunteers

    Quantitation of Bemnifosbuvir and Metabolites in Human Bronchoalveolar Lavage by LC-MS/MS

    PCR's Key Role in Therapeutic Advancements

    Cell and gene therapies are revolutionizing medicine with personalized treatments; PCR analysis plays a crucial role in their development.

    In this issue of The Altascientist:

    - explore the different approaches and applications of qPCR and ddPCR analysis for nonclinical and clinical studies;
    - discover the unique advantages they offer; and
    - review two case studies demonstrating how these methods are shaping the future of gene therapy research.


    Have questions? Speak to a scientist.

    READ NOW

    ​​​​​Altasciences transforms the traditional outsourcing paradigm by simplifying and streamlining drug development solutions, whether for a single study or multiple programs, to offer an integrated/synchronized approach to CRO and CDMO services from lead candidate selection to clinical proof of concept, and beyond.​​​​

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