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  • Ecm85, CC BY-SA 3.0 <>, via Wikimedia Commons
    Ecm85, CC BY-SA 3.0 via Wikimedia Commons

    My fellow Altascientists and I recently attended the 2024 annual Boston Society Gen

    Maximize Assay Sensitivity and Minimize Costs

    Strategies to Improve Assay Sensitivity to Quantify Therapeutic Oligonucleotides

    Are you looking for assays with enhanced sensitivity and minimal sample clean-up in small volumes?

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    Our strategies enhance analytical sensitivity, reduce assay costs, and streamline workflows, optimizing the efficiency and cost-effectiveness of your research and development processes.

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    ​​​​Strategies to improve assay sensitivity to quantify therapeutic oligonucleotides

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    Sensitive Quantitation of Antisense Oligonucleotides Using Capitainer® qDBS Microsampling Device Coupled with Hybridization LC-MS/MS

    Antisense oligonucleotides—or ASOs—are short, synthetic, single-stranded oligonucleotides  extensively used for altering RNA expression to reduce, restore, or modify protein expression via several distinct mechanisms. With possible applications extending to both neurological and non-neurological conditions, there is great potential for valuable new therapeutics. 

    Strategies to Improve Assay Sensitivity to Quantify Therapeutic Oligonucleotides

    Singlicate Analysis in Ligand Binding Assays From Discovery to Regulated Clinical Studies: Implementation Strategies and Benefits

    FREE ON-DEMAND WEBINAR—Key Considerations for Nonclinical AAV Gene Therapy


    From Screening to PCR Analysis

    In this webinar on AAV gene therapy, we explore pre-existing immunity challenges, vector targets, biodistribution, and the role of PCR analysis in assessing therapy efficacy and safety.

    Also included are case studies that highlight the delicate balance between innovation and regulatory compliance.

    Watch now!

    ​​​​Webinar BioAnalysis Gene Therapy


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    ​​​ ​​​​​​​​​​​​The Altascientist
        •   qPCR and ddPCR—Leading-Edge Analysis for Gene Therapy Programs
         •  Nonclinical Studies in Cell and Gene Therapy

         •  Bioanalytical Services
         •  Preclinical Services


    The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. The goal is to safely incorporate genetic alterations to restore and repair the proteins of missing and/or faulty genes.

    Strategies for Safe and Timely Shipments


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    Sample Logistics

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