Jeff received his graduate degree in Chemistry from Queens University. He focused the first decade of his career in mass spectrometry on instrumentation research and product development, designing novel scan functions for both 2D and 3D ion traps.

Hybridization LC-MS/MS Workflow to Quantify an siRNA Drug Candidate in Plasma, CSF, and Tissues

Timely completion of necessary studies is a critical element of drug development, bringing important treatments to patients in a safe and cost-efficient way. A consideration with a measurable impact on early-phase clinical studies is the location where trials are performed; this is especially true for first-in-human (FIH) trials.

Conducting early-phase clinical research on novel compounds in Canada can provide significant advantages versus other locations.

In Issue 31 of The Altascientist, we take a deep dive into these advantages, covering:

  • Canadian CTA trials–time and cost savings
  • Regulatory review process predictability
  • Business efficiency cost savings
  • Clinical trial participants
 

 

Scratching the Surface of Dermal Testing

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Opinion | A Day to Celebrate, and a Call to Action

Dr.

Case Study―Evaluating Milling Conditions for Scaling Up a Nanosuspension Drug Product

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Opioids are highly effective at relieving both acute and chronic pain. However, this benefit comes at a significant cost: they are also highly addictive.

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The drug development landscape is constantly evolving, with science and technology advancing hand-in-hand to improve the essential steps of determining drug concentration profiles and the characterization of drug transformation products. The ultimate goal is to better understand drug distribution, metabolism, and pharmacokinetic characteristics, and to present regulatory bodies with a complete and comprehensive submission package driven by current guidelines.

To this end, liquid chromatography (LC) coupled with mass spectrometry (MS) via an atmospheric pressure ionization (API) interface is a well-established analytical approach to support each phase of drug development, from early discovery through to clinical studies.

In Issue 30 of The Altascientist, we explore the numerous benefits of incorporating a stable isotope labelled internal standard for quantitative LC-MS, and detail recent advances in MS technology, including: 

  • stable isotope labelled internal standards (SLIS) for LC-MS quantitation
  • dried blood microsampling
  • anti-epileptic drug panel
  • COVID-19 neutralizing monoclonal antibodies
  • differential mobility spectrometry
  • bioequivalence
  • large molecule bioanalysis
  • oligonucleotides

Also included are several case studies, which exemplify novel bioanalytical workflows that are required to meet the challenges faced in both nonclinical and clinical development, across a variety of drug classes.

 

 

 

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