Bioanalysis

  • Bioanalysis
  • A Multi-Peptide Hybrid LC-MS/MS Assay for the Determination of CTI-1601 in Monkey Tissues Provides Insight into its Disposition and Processing

    Quantitation of a PEGylated Human Parathyroid Hormone (1-34) Analog in Rat Plasma Using a Hybrid Immunoaffinity Bottom-Up LC-MS/MS Assay

    The Application of Light-Absorbing Photostabilizers for the Determination of Protoporphyrin IX in Human Plasma by LC-MS/MS

    Overcoming Recovery Challenges in Hemolyzed Samples for the Determination of Propafenone and 5-Hydroxy Propafenone by LC-MS/MS

    Altasciences talks benefits of using SCIEX's SelexION technology for bioanalysis

    Scienx's Selexion Technology

    At Altasciences, we pride ourselves on the wide range of bioanalytical services we offer to support drug development, from discovery to preclinical to phase IV — method development, validation, and sample analysis — using the most innovative technologies to meet your needs with a patient-centric approach.

    A recent article in the SCIEX VISION journal (pages 22-23) explores the expertise and workflows leveraged by our scientists at Altasciences to support emerging technologies, such as Volumetric Absorptive Microsampling (VAMSTM) and the use of the SelexION Ion Mobility device to overcome selectivity and sensitivity challenges.

    Jeff Plomley

    In case you missed them – our posters presented at the WRIB conference

    Posters - 13th Annual Workshop on Recent Issues in Bioanalysis (WRIB)

    Altasciences' Method Development and LBA experts presented two posters at the WRIB conference. Don't miss out on the latest advancements contributing to our bioanalytical capabilities and ingenuity.

    When Validated Collection Procedures Differ From Clinical Sample Processing: A Lesson in Adaptability for the Determination of Rifampin

    Method Validation for the Determination of AST-008 in Human Plasma Using Hybridization-Ligation Electrochemiluminescence (ECL)

    Presented by: Josee Michon

    Presented by: Danielle Salha

    Get in touch with one of our scientific experts for answers to all your questions and to discuss your study needs.

    Ask our experts

    BIOAVAILABILITY/BIOEQUIVALENCE

    BIOAVAILABILITY/BIOEQUIVALENCE

    Altasciences has been at the forefront of bioavailability (BA) and bioequivalence (BE) testing for over 25 years. With extensive expertise working on a variety of compounds, we have an exceptional reputation for successfully conducting simple to complex BA/BE trials and have experience with regulatory agencies across the world.

    We have a large pharmacokinetics (PK) database, which has supported the design and conduct of over 2 600 studies in hundreds of medications. Our PK database contains invaluable details of the design as well as the variability observed in previous studies, providing us with important data to calculate the required sample size. Our expertise covers the full range of drug administration routes, giving us a firm understanding of the specific PK requirements of each dosage form. We routinely develop and validate new bioanalytical methods for novel compounds so that we are ready when you need them. We have developed over 620 methods, all of which are reliable and reproducible, for your drug discovery and development.

    Our fast recruitment and excellent retention rate will help you complete your study faster. With 600 beds at your disposal across three strategically located facilities in the U.S. and Canada, Altasciences has the capacity to conduct multiple-arm studies, or multiple studies at the same time.

    Why should you work with us?
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    Supporting your Large Molecules ― from Discovery to Preclinical to Clinical Pharmacology

    Altasciences recently expanded its bioanalytical laboratory by adding space dedicated to ligand binding and cell-based assays, to continue to support and deliver quality bioanalytical solutions to our clients. The new, larger space is fully equipped to respond to the high demand of cell-based neutralization and functional assays for biologics and vaccines. We now have the additional capacity for cell lineage and functional immuno-phenotyping by flow cytometry to support both preclinical and clinical studies.

    Bioanalytical Support for Your Large Molecules

    Renowned for our vast experience in LC-MS/MS and Ligand Binding bioanalytical platforms, our team of dedicated scientists in both the U.S. and Canada provide a comprehensive suite of bioanalytical services, from discovery to preclinical to phase IV. They evaluate each request and provide customized workflows to allow accurate quantitation using the appropriate platforms (Mass Spectrometry and/or Ligand Binding).

    Why do clients appreciate working with us? Because each bioanalytical phase of your study ― method development, validation, and sample analysis ― has a Method Development Expert and/or a Bioanalytical Principal Investigator with the appropriate scientific and regulatory expertise assigned.

    Let's discuss your bioanalytical needs and how our solutions can support your preclinical and/or clinical research.

    Method Development for the Detection of Exicure’s AST-008 in Human Plasma

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