Choosing the right bioanalytical platform for your molecule’s intended use and program segment is crucial to obtaining reliable, robust data in a timely manner. At Altasciences, our bioanalytical experts will determine the best approach for sample processing and analysis according to your molecule.
Key Considerations to Influence Bioanalytical Platform Selection
Our experts take time to fully understand all the aspects of your program, and knowing the attributes of each bioanalytical platform, recommend the most appropriate, effective solution based on these key considerations.
1. Study Endpoints
The specific endpoints of your study are a major driver of decisions around platform selection. The platform selected should be appropriate for your molecule and specific phase of study, and ideally positioned to deliver the precise, quality data you need.
Whether your budget is minimal or significant, cost-effectiveness of the proposed solution is an important factor. The solutions required for certain programs are, by their nature, more costly and/or time-consuming than others. We will help you select a platform that is aligned with your study objectives, timeline, and budget.
3. Efficient Characterization of ADME
A critical feature of the bioanalytical platform selected for a drug development program is how well it characterizes the ADME (absorption, distribution, metabolism, excretion) of your molecule of interest. This data represents approximately 25% of the information in the eventual drug label, and it must be of the highest quality.
4. Platform Selectivity and Sensitivity
With the above information to consider, the features of each platform are the final variable. The available bioanalytical platforms each have distinct benefits for a particular set of conditions, see Figure 1.
Altasciences’ Bioanalytical Capabilities and Expertise
In addition to platform selection expertise, we have a proven history of on-time delivery, and sufficient capabilities to ensure efficient and effective project progression. Our multiple bioanalytical sites provide redundancy in equipment and expanded resource capability, ensuring that your timelines are met.
Our bioanalytical team specializes in ligand binding assays, mass spectrometry, flow cytometry, Elispot, and PCR, from discovery to preclinical to Phase IV, and beyond. We have expertise in immunology, biomarkers, oligonucleotides, and many other areas to support whatever your program requires.
Altasciences’ Bioanalytical Locations
We operate in three strategic locations near or at our preclinical and clinical sites, providing full-service bioanalysis to meet your everyday requirements. Our solutions include standalone services or integrated programs, providing assay development and top-quality data for toxicokinetic (TK), pharmacokinetic (PK), and pharmacodynamic (PD) determinations to support your nonclinical and clinical studies.
Why Partner With Altasciences for Your Bioanalytical Projects?
Our flexible, agile, and innovative scientists expedite your research goals by efficiently determining which bioanalytical platform is most appropriate for your molecule, and which assays will deliver the reliable and relevant data you require. With our in-house database of over 680 validated assays, as well as the ability to provide customized workflows and methods using advanced instrumentation and state-of-the-art bioanalytical platforms, we can help you make the right decisions. Contact us today to get started.