Preclinical Research
Highlights From the 17th Minipig Research Forum, by Shanté Jackson
I recently had the chance to attend the 17th Minipig Research Forum (MRF) in Amsterdam—and what an experience! This was my first time attending the forum, and visiting the Netherlands!
Consultant’s Corner—Reflections from a Study Monitor and Director: A Career in Toxicology, by Bill Brock
Some might say a reflective piece like this could come across as sounding “preachy”. Maybe it is. But it is reflective of a long and rewarding career built on the belief that we as scientists need to give back to the field of toxicology, supporting the growth of future leaders.
Highlights From the 2025 Society of Toxicology 64th Annual Meeting With Dr. Marianna Bacellar-Galdino, DVM, MSc, PhD
I had a fantastic time connecting with colleagues, clients, and peers at the Society of Toxicology (SOT) 64th Annual Meeting in Orlando, Florida. As my first SOT experience, I truly enjoyed the vibrant, enthusiastic atmosphere.
Case Study: How Altasciences Overcame Pharmacological Challenges in a GLP-1 IND-Enabling Study
For emerging therapies with pronounced pharmacological effects, thoughtful study design is critical to ensuring reliable and interpretable data.
Hybridization LC-MS/MS for Sensitive Quantitation of Antisense Oligonucleotides in Plasma and Dried Blood Microsamples
Best Practices for Preclinical Dose Range Finding Studies
Dose range finding (DRF) studies are the foundation of preclinical drug development, providing crucial information on safety data to assist in the dose level selection before advancing into to
Inside Preclinical Ocular Research: With Dr. Simone Iwabe, DVM, PhD, DACVO, and Randy Wheeland, BS
Altasciences has been at the forefront of ophthalmic drug development for over 30 years, having completed more than 100 ocular studies to assess the safety of new drug products intended for human use.
ISSUE NO. 43 — Advancing Vision Care With Formulation and Manufacture of Ocular Therapeutics
According to the WHO, at least a billion people are currently living with vision impairment from a preventable or treatable source. Precedence Research reports that the global ophthalmic drug market size is estimated to double in 10 years, from $34.6 billion in 2021 to an estimated $68.93 billion by 2030.
The development of pharmacological interventions for many of these conditions has been accelerating, supported by new delivery methods and formulation approaches. For conditions that require surgery or corrective devices, eye drops are an important part of diagnosis, and pre- and post-surgery treatment plans.
In Issue 43 of The Altascientist, we explore key considerations for ophthalmic product manufacturing, including formulation, scalability, regulatory compliance, and quality control:
- Recent developments in ophthalmic medications
- Unique barriers for drug delivery to the eye
- Common types of ocular formulations
- Formulation for effective ocular drug delivery
- Systemic exposure of topical ophthalmic preparations
- Ocular gene therapy
- Manufacturing ocular drugs for clinical trials and commercialization
- A case study
Subretinal Injection of Sodium Iodate Creates a Geographic Atrophy-Like Model in Nanopigs™