Preclinical Research
Introducing Philippine-Origin Cynomolgus Macaque As a Research Model
Understanding Species Variation in the Occurrence of Spontaneous Background Eye Lesions
Comparison of Cardiovascular and Respiratory Parameters in Three Strains of Research Pigs
Creation of a Swine Model of Oral Angioedema
Historical Review of In-Life Data From Studies Utilizing AAVs for Gene Therapy
Intravenous Sampling and Administration in Rodents
Proposed Best Practices for Optimizing the Number of Animals in Toxicology Studies
Drug Development for Cell and Gene Therapy
In this scientific journal, we review considerations for nonclinical cell and gene therapy development, including expert approaches to mitigating complex challenges, improving study efficiency, and maximizing translational opportunities from nonclinical to first-in-human trials.
Learn about:
• the ICH S-12 Guideline on nonclinical biodistribution studies
• species selection criteria per the FDA
• choosing the appropriate vector
• immunogenicity evaluations
• findings from two case studies
Read the issue HERE.
Ready for the next step? Contact one of our experts to discuss your study needs.
You may also be interested in the following:
• Webinar: Cell and Gene Therapy―Enhanced CNS and Ocular Delivery in NHPs
• Poster: Gene Therapy Utilizing Adeno-Associated Viral (AAV) Vectors―Historical Data Review
• Webpage: Preclinical Research Services
Development of a Novel Canine Prostatectomy Model